How Medicines Work 2. Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma

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Carbonic Anhydrase Zinc coordination Sulfanilamide MK417 Stereochemistry Dorzolamide analogue Sulfonamide interactions Hydrogen bonds van der Waals interactions Thermodynamic considerations Structure of the beta-2 receptor HBI HBI bound to the Beta-2 Adrenoceptor HBI bound to the Beta-2 Adrenoceptor HBI bound to the Beta-2 Adrenoceptor HBI bound to the Beta-2 Adrenoceptor Molecular model of acetylcholine Molecular model of cis-ACTM Molecular model of trans-ACTM Trans-ACTM (green carbon atoms) superimposed with muscarine (grey carbon atoms) Overlay of three muscarinic agonists Overlay of an agonist and a muscarinic antagonist Nicotine + Cytisine + ARR-17779 (Superimposed) Acetylcholinesterase Cyclohexane chair Cyclohexane boat Cyclohexane twist boat